Your guide to peptides,
grounded in evidence.
Explore 237 peptides with honest evidence ratings, safety profiles, and research-backed content. Built for the curious, not the credulous.
237 peptides, each graded across 5 evidence tiers and organized across 9 health goals, with every claim linked to PubMed and research gaps flagged honestly.
Explore by goal
What are you looking to support? Start with your health objective and discover relevant peptides.
Recovery & Repair
Peptides discussed for supporting tissue healing, injury recovery, and physical repair processes.
Sleep & Mood
Peptides explored for their potential effects on sleep quality, stress resilience, and emotional well-being.
Weight Loss
Peptides studied for their effects on appetite, fat metabolism, and sustained weight loss.
Body Composition
Peptides studied for their potential effects on fat metabolism, muscle preservation, and growth hormone optimization.
Cognitive Support
Peptides explored for their potential effects on focus, memory, neuroprotection, and overall brain health.
Longevity & Anti-Aging
Peptides studied for their potential effects on cellular aging, telomere maintenance, and age-related decline.
Skin, Hair & Aesthetics
Peptides explored for skin rejuvenation, hair growth, wound healing, and cosmetic applications.
Gut & Inflammation
Peptides studied for gut health, immune modulation, and inflammatory conditions.
Explore by family
Mechanism- and lineage-driven peptide classes — copper peptides, GLP-1 agonists, melanocortins, and more. Each family page covers shared mechanism, history, and links to every member.
GLP-1 & Incretin Agonists
The peptide drug class that has reshaped diabetes and obesity care over 2005-2026 — GLP-1 receptor agonists plus the dual GLP-1/GIP and triple GLP-1/GIP/glucagon multi-receptor agonists. Founded by exenatide (a venom-derived peptide approved 2005) and now anchored by semaglutide, tirzepatide, and retatrutide, with cardiovascular, kidney, and MASH outcomes data.
Copper Peptides
A family of small copper-binding tripeptides — GHK-Cu, AHK-Cu, and palmitoyl variants — that form stable copper(II) complexes with documented effects on collagen synthesis, wound healing, and skin remodeling. Founded by Loren Pickart's 1973 isolation of GHK-Cu and now a fixture of cosmetic dermatology and the wound-care literature.
Melanocortins
The peptide family of α-MSH analogs and selective melanocortin-receptor agonists — covering pigmentation (afamelanotide, melanotan-II), monogenic obesity (setmelanotide), and female sexual desire (bremelanotide / PT-141), plus the immunomodulatory KPV tripeptide and the cosmetic α-MSH analog nonapeptide-1.
Growth Hormone Secretagogues
The peptide family that stimulates pulsatile endogenous growth hormone release rather than supplying exogenous GH directly. Two mechanistic branches: GHRH analogs (sermorelin, CJC-1295, tesamorelin) acting at the GHRH receptor, and ghrelin receptor agonists (GHRP-2, GHRP-6, hexarelin, ipamorelin, MK-677/ibutamoren) acting at GHSR1a. Often stacked together for synergistic GH pulses.
Amylin Analogs
The peptide family of synthetic amylin agonists — pramlintide (FDA-approved 2005 for diabetes adjunct), cagrilintide (long-acting weekly amylin in CagriSema combination with semaglutide), petrelintide and eloralintide (next-generation Phase 2/3 amylin analogs), plus the multi-receptor amycretin (amylin+GLP-1). Amylin co-administered with GLP-1 has emerged as the dominant combination strategy for next-generation obesity pharmacotherapy.
Cosmetic & Signal Peptides
The cosmetic peptide actives applied topically for skin aging, wrinkles, and pigmentation — including argireline (acetyl hexapeptide-8, the SNAP-25-targeting 'topical Botox' analog), matrixyl (palmitoyl pentapeptide-4, the matrikine collagen stimulator), syn-ake (the snake-venom-derived nicotinic-receptor antagonist), SNAP-8, vialox, rigin, and the broader cluster of palmitoylated tripeptides, palmitoylated tetrapeptides, and signal peptides used in cosmetic formulations.
Collagen Peptides
Two distinct meanings of 'collagen peptide' that consumer marketing often conflates: (1) oral hydrolyzed-collagen protein supplements (gelatin-derived powders sold for skin, hair, and joint health) with modest RCT support for skin elasticity and moisture, and (2) cosmetic 'matrikine' peptides (Matrixyl, syn-coll, palmitoyl-tripeptide-1, GHK-Cu) that stimulate fibroblast collagen synthesis topically. Different molecules, different routes, different evidence bases.
Thymic Peptides
The peptide family derived from thymic tissue and its synthetic analogs — Thymosin α-1 (Zadaxin / thymalfasin, immune modulation), Thymosin β-4 (TB-500, tissue repair through actin sequestration), Thymalin (Russian-tradition thymic-extract preparation), Thymulin (zinc-dependent thymic hormone), and Thymagen (Khavinson-program synthetic thymic peptide). Two functional branches: α-family for immune function, β-family for actin-mediated tissue repair.
Somatostatin Analogs
The peptide family anchored by somatostatin (SRIF, isolated by Brazeau and Vale at the Salk Institute in 1973) and its long-acting synthetic analogs — octreotide (Sandostatin), lanreotide (Somatuline), pasireotide (Signifor) — used clinically for acromegaly, neuroendocrine tumors, Cushing's disease, and post-operative pancreatic fistula prophylaxis. The endogenous family also includes cortistatin, the somatostatin paralog with overlapping but distinct pharmacology.
GnRH Agonists & Antagonists
The peptide family of synthetic gonadotropin-releasing hormone (GnRH) agonists and antagonists — leuprolide, triptorelin, goserelin, buserelin, nafarelin, histrelin (agonists) and degarelix (antagonist) — used clinically for prostate cancer, endometriosis, central precocious puberty, and IVF cycle regulation. Plus the upstream master regulator kisspeptin and the diagnostic prototype gonadorelin.
Natriuretic Peptides
The cardiac and vascular peptide family centered on atrial natriuretic peptide (ANP, de Bold 1981), B-type natriuretic peptide (BNP, Sudoh 1988), and C-type natriuretic peptide (CNP, Sudoh 1990) — the endogenous regulators of vascular tone, sodium balance, and fluid homeostasis. Plus nesiritide (recombinant BNP, FDA-approved 2001 for acute heart failure) and the related vascular peptide adrenomedullin.
Endogenous Opioid Peptides
The endogenous peptide ligands of the mu, delta, and kappa opioid receptors — the enkephalins (Hughes & Kosterlitz 1975), beta-endorphin, dynorphin (Goldstein 1979), endomorphin-1 and -2, nociceptin/orphanin FQ, plus food-derived exorphins (casomorphin) and the indirect opioid analgesic kyotorphin. The neurobiological basis of endogenous pain modulation, reward, and stress response.
Antimicrobial Peptides
The peptide family of host-defense antimicrobial peptides — LL-37 (the human cathelicidin), KPV (the alpha-MSH-derived anti-inflammatory tripeptide), lactoferricin (the lactoferrin-derived antimicrobial), DS-5, plus the broader research-tier cluster including tuftsin, hepcidin, and larazotide. Antimicrobial peptides are an active drug-development area for resistant infections, mucosal immunity, and inflammatory disease, with origins traceable to Michael Zasloff's 1987 discovery of the magainins.
Khavinson Bioregulators
A catalog of synthetic short peptides (typically 2-4 amino acids) developed at the St. Petersburg Institute of Bioregulation and Gerontology since the 1970s, positioned as tissue-specific epigenetic regulators of gene expression. The catalog spans 20+ entries — Epitalon, Cortagen, Pinealon, Vilon, Thymalin, Cardiogen, Bronchogen, and others — each targeted at a specific organ. A real Russian peer-reviewed literature with substantial preclinical depth, but a mechanistically speculative framework that has not been validated to mainstream Western molecular-biology standards.
Most popular peptides
The peptides generating the most interest in the community. Each entry is evidence-graded and research-backed.
BPC-157
Gastric Peptide
A synthetic peptide derived from a protective protein found in gastric juice, widely discussed for tissue repair and recovery.
TB-500
Tissue Repair Peptide
A synthetic version of the active region of thymosin beta-4, widely used for tissue repair, wound healing, and recovery from injuries.
CJC-1295
GHRH Analog
A growth hormone-releasing hormone analog that stimulates the pituitary gland to produce more growth hormone.
Ipamorelin
Growth Hormone Secretagogue
A selective growth hormone secretagogue that stimulates GH release without significantly affecting cortisol or prolactin.
Semax
Nootropic Peptide
A synthetic peptide analog of ACTH(4-10) developed in Russia, studied for cognitive enhancement and neuroprotection.
GHK-Cu
Copper Peptide
The most-studied copper peptide in skincare — a naturally occurring tripeptide (GHK, Gly-His-Lys) whose active tissue form is the copper complex GHK-Cu, with extensive evidence for skin remodeling, collagen synthesis, wound healing, and anti-aging.
Evidence, not hype.
Every peptide on this site is graded across five evidence tiers, from Strong (multiple human RCTs) to Limited (mostly mechanistic). We link every claim to PubMed and flag research gaps honestly. Built for the curious, not the credulous.
See our evidence framework